Answer the questions for Cases Essay Example | Topics and Well Written Essays - 2000 words

Answer the questions for Cases - Essay Example The analysis of these above mentioned three concepts by Build-A-Bear executives enables them to devise effective innovative strategies and plans that fulfill all the basic demands of their clients while simultaneously resulting in increased brand awareness, customer satisfaction and loyalty. The Build-A-Bear workshop actually believes in selling an experience or personalized entertainment to its clients than just selling an ordinary product or a service for some money. Build-A-Bear is actually a workshop that allows preteens to create their teddy bears through a step-by-step production process. The first step is called â€Å"Choose me† in which a child pick an unstuffed animal followed by a second stage known as â€Å"Stuff me† in which a child a child operates a foot pedal that blows in the amount of fluff. Third stage â€Å"Hear me† is about including a voice box followed by a â€Å"Stitch me† stage in which the animal is stitched. The last two stages are known as â€Å"Dress me† and â€Å"Name me† stages in which a child has to cloth his or her animal and finally give it a nick name of their choice respectively. This workshop actually shares adorable memories of creating and preparing an animal in exchange of money. The entir e process is not only enjoyable but it is being remembered by young that later compels to try this workshop again and again. The marketing management concept of Product Development best describes the Build-a-Bear workshop. This concept is actually a business growth strategy that aims to generate excessive revenues by offering new products to existing group of customers. The additions and offerings of new products such as mini-scooters, mascot bears, in-store galleries of bear-sized furniture, spider costumes and sequined purses based on innovative ideas of customers greatly contributed in company’s success and goal accomplishment. Furthermore, the workshop is coming up with further innovations,

Arab world Article Example | Topics and Well Written Essays - 750 words

Arab world - Article Example (2007: p 364) Same is the case with the Arab world, which maintains its unique ethnographic identity, historical background, ancestry, cultural traits, social norms, moral values, religious beliefs and genealogy. The people speaking Arabic as their primary or first language are called the Arabs. â€Å"The Arab world†, Tamari views, â€Å"is not to be confused with the â€Å"Middle East,† a strategic designation developed during the heyday of the British Empire, which encompasses such non-Arab countries as Israel, Iran, Turkey, Pakistan, and Afghanistan. And though Arab history is intertwined with Muslim history, the Arab world does not correspond to the Muslim world.† (Quoted in ccas.georgetown.edu) At present, the total Arab population, inhabited in twenty three countries of the world, has been estimated to be about 325 million with 2.3% annual increase. (UNFPA 2007) The have been articulated divergent propositions regarding the origin and background of the Arabs. One school of thought declares that the Arabian Peninsula is the origin of the Arabs, and the Bedouin clans of that region are the forefathers of them, who had been living there far before the birth of Abraham in Babylonia. The first positive reference to the Arabian extant occurs in an inscription of the Assyrians, Shalmaneser III, who speaks of the capture of a thousand camels from Gindibu, the Arabia, in 854 B. C. (Landau, 1958: 11-21: quoted in bible.ca) In addition, It had mistakenly been considered that all Arabs are the descendents of Ismail (Ishmael) the elder son of Abraham. The basic source of this information is the Semitic religions and a large majority of the Abrahamic religions, including Jews, Christians and Muslims, view Ismail as the father of the Arabs. According to the Jewish sources, it was Ishmael, whose descendents were blessed and multiplied as a great nation: â €Å"God heard the boy (Ishmael) crying, and the angel of God called to Hagar from heaven and said to her, "What is the

Dictyostelium as a Predictive Model for Bitter Tastant

Dictyostelium as a Predictive Model for Bitter Tastant Developing Dictyostelium as a Predictive Model for Bitter Tastant Identification INTRODUCTION Bitter tastant (emetic) research utilises a variety of animal models for the identification of the emetic susceptibility of novel compounds and aim to characterise the underlining mechanisms that give rise to emesis. There are two categories of animals used in this type of research, those that have the ability to vomit (ferrets, dogs and cats), and those that lack the emetic reflex (rats and mice) (Holmes et al., 2009). In addition to this, there is a different sensitivity to emetic compounds amongst these animal models, due to the existence of multiple pathways for the emesis induction. There are also differences in the receptor pharmacology and distribution, and metabolic pathway regulation. This makes it very hard to use a unique animal model for emetic research, pushing research towards a multi-model approach, therefore increasing the utilisation of animals (Robery et al., 2011). Ingestion of bitter tastants can lead to innate aversive behaviour, reduced gastric emptying, nausea and vomiting in mammals and as such bitter tastants are thought to provide a potentially vital warning sign of toxicity (Robery et al., 2011). Humans recognise thousands of different compounds as bitter. Despite this ability only around 25 taste 2 receptors (TAS2R) have been identified. Common bitter ligands include cycloheximide, denatonium, PROP (6-n-propyl-2-thiouracil), PTU (phenylthiourea), and ÃŽ ²-glucopyranosides (Meyerhof et al., 2010). As previously stated, bitter substances are detected by a specific subset of taste receptors, known as BITTER TASTE-SENSING TYPE 2 receptors (TAS2Rs) (Meyerhof et al., 2010). These are part of the superfamily of G protein-coupled receptors (GPCRs) and can be found on cell surface that mediate gustatory taste perception on the tongue. Signal transduction of bitter stimuli is accomplished via the ÃŽ ±-subunit of gustducin (Gulbransen et al., 2009). This G protein subunit activates a taste phosphodiesterase and decreases cyclic nucleotide levels. The ÃŽ ²ÃŽ ³-subunit of gustducin also mediates taste by activating IP3 (inositol triphosphate) and DAG (diglyceride). These second messengers may open gated ion channels or may cause release of internal calcium. Although all TAS2Rs are located in gustducin-containing cells, knockout of gustducin does not completely abolish sensitivity to bitter compounds, suggesting a redundant mechanism for bitter tasting (unsurprising given that a bitter tas te generally signals the presence of a toxin). One proposed mechanism for gustducin-independent bitter tasting is via ion channel interaction by specific bitter ligands, similar to the ion channel interaction which occurs in the tasting of sour and salty stimuli (Gulbransen et al., 2009). The properties of TAS2Rs are different from other GPCRs, because of the ability of binding a wide range of compounds with low specificity and affinity. TAS2Rs have recently been suggested to have important extra-oral functions in the respiratory and gastrointestinal tracts. In the human airway epithelium TAS2Rs are expressed on the solitary chemosensory cells and ciliated epithelial cells, where they sense chemical irritation and promote ciliary beat frequency, respectively. Thus TAS2Rs may be protective and part of the defence against inhaled noxious compounds (Zhang et al., 2013). Recent studies have found that in resting primary airway smooth muscle cells, bitter tastant activate TAS2R-dependent signalling pathway that results in an increase in [Ca2+]i levels, although to a level much lower than that caused by bronchoconstrictors (2-adrenoceptor agonist) (Zhang et al., 2013). Under physiological circumstances, bitter tastants can activate TAS2Rs to modestly increase [Ca2+]i levels without affecting contraction, but in the situation of muscle constriction, they can block L-type calcium channels to induce bronchodilation (Zhang et al., 2013). TAS2R agonists showed both greater relaxation and inhibition of airway hyper-responsiveness than a ÃŽ ²2-adrenoceptor agonist in mouse airways. Given the large selection of known natural and synthetic agonists recognized by the 25 TAS2Rs, the findings have introduced bitter taste receptors as a potential new family of targets for asthma pharmacotherapy (Zhang et al., 2013). Dictyostelium as  a biomedical model organism D. Discoideum is a well-established research model organism, especially in investigating chemotaxis. D. Discoideum is a social amoeba that feeds on bacteria as its staple food source. Once the food supply is exhausted, cells start a developmental program leading to the production of spores that are able to survive in hostile conditions (Frey et al., 2007). Starving cells produce a chemo-attractant, cyclic AMP (cAMP), which serves as a signal for 1 x 105 neighbouring cells to aggregate, which then develop into a mature fruiting body (after 24 hours), where 20% of the cells form a stalk that supports a spore head incorporating 80% of the remaining cells as spores. When food sources are available again, the spores germinate into amoebae, completing the life cycle (Figure 1) (Frey et al., 2007). (Frey et al., 2007) Figure 1 D. Discoideum, develops from a single vegetative amoebae (0hrs) through to the generation of the mature fruiting body (24hrs). Aggregation is caused by the chemotaxis of cells toward cAMP waves to give rise to a multicellular aggregate. Aggregation results in the creation of a mound, then a tipped mound, and as development proceeds, the tip prolongate and forms a finger. Ultimately, the finger collapses to form a slug or continues to form a fruiting body. During final stage of the development, the cells differentiate into vacuolated stalk cells that sustain a spore head containing spores, which can tolerate a wider range of environmental conditions. The full developmental process from starvation of vegetative cells to the formation of a mature fruiting body is accomplished in 24 h (Frey et al. 2007). D. Discodeum has been extensively utilised to investigate a range of fundamental biological processes such as cell migration, signal transduction, phagocytosis and signalling during morphogenesis and cell differentiation. The fully sequenced genome contains 34 Mb of DNA (84-fold smaller than the human genome). D. Discoideum has a genome that encodes for a variety of proteins that are human homologues, associated with a variety of disorders (Boeckeler et al., 2007). Therefore, it has been suggested that the primary role of those proteins can be analysed in the model to understand their related disease function. Nausea and vomiting are common but serious side effects associated with many therapeutic drugs. Whilst the physiological mechanisms behind the generation of the vomiting response are well characterised, the diverse range of emetic stimuli that can generate the response are poorly understood. The potential of using D. Discoideum, a eukaryotic amoeba, as a model for predicting emetic liability was examined in this thesis. The effects of a diverse range of known emetic and aversive compounds on Dictyostelium cell behaviour was investigated, resulting in the identification of a small number that strongly inhibit cell behaviour in a concentration-dependent manner. Recent studies using Dictyostelium as a simple model system for bitter related (emetic) research has shown the validity of using this approach for the reduction of animals in testing for emetic liability. Even though Dictyostelium does not contain genes encoding homologues to T2R proteins associated with bitter compounds detection, it has been identified the molecular mechanism responsible of PTU detection. The screening of mutants resistant to the effects of PTU on growth identified a putative G-protein coupled receptor mutant, GrlJ-. Translation of this discovery to human context identified an uncharacterised human gamma-aminobutyric acid (GABA) type B isoform, with a relatively weak homology to GrlJ. The expression of the human GABA-B receptor restored GrlJ- sensitivity to PTU, implicating this human protein as a novel receptor for PTU. In addition, GrlJ only partially controls PTU detection but not detection for all bitter substances. This research was carried out by monitoring the cell behaviour (motility, circularity, protrusions formation and displacement) following exposure to a range of known emetic compounds. Results show that bitter tastants cause an acute, marked and concentration dependent effect on cell behaviour. Therefore, this suggests that Dictyostelium may guarantee a new model for the analysis and screening of novel bitter/emetic compounds, and therefore reducing the utilisation of animal models by identifying the best candidates in a range of molecules. In this study a range of eight compounds were tested to investigate their effects on Dictyostelium random cell movement. The compounds list was specifically created to understand if the model system was able to predict the bitterness of those compounds and ultimately obtain a ranking order comparable to the in vivo rat brief access taste aversion (BATA) and human sensory panel models (Rudnitskaya, et al., 2013). The set of substances consisted of both organic and inorganic – azelastine, caffeine, chlorhexidine, potassium nitrate, paracetamol, quinine and sumatriptan. Results have shown that the bitterness ranking order obtained by using random cell movement assays was comparable to the one obtained with the BATA and the human sensory panel models. In particular, amongst those compounds, Azelastine, a selective (non-sedating) H1 antagonist structurally similar to other anti-histaminic molecules has shown to be one of the most potent compounds in the inhibition of Dictyostelium cell behaviour. This bitter-tasting compound is pharmacologically classified as a 2gen antihistamine, with relative lack of CNS (central nervous system) activity. Clinical trials, in vitro and in vivo studies have shown the combined effect of direct inhibition and stabilisation of inflammatory cells. In vitro studies suggest that the affinity of azelastine for H1 receptors is several times higher than that of chlorpheniramine, a 1gen H1 antagonist. Azelastine directly antagonizes TNF-ÃŽ ±, leukotrienes, endothelin-1, and platlet-activating factor. In vivo studies in a guinea pig model have demonstrated that both histamine-related and h-independent bronchoconstriction were inhibited by azelastine (Williams et al., 2010). The second most potent compound tested is Chlorhexidine (CHX), a broad spectrum antimicrobial agent, frequently used in dental-care to inhibit bacterial growth and in periodontal disease prophylaxis. It is classified as antibacterial, but it can also interfere with the proteolytic activity of some periodontal pathogens. This inhibitory effect is associated with its chelating properties (Trufello et al., 2014). One of the chemicals used as standard for bitterness measurements is Quinine, a natural occurring alkaloid with different medicinal properties, such as antipyretic, antimalarial, analgesic, and anti-inflammatory activities. Methods D. discoideum discoideum maintenance Cells and spores were stored at -80  ºC, and every month an aliquot of the frozen stock was collected and placed on a Raoutella planticola bacterial lawn. After 3-4 days, plaques of growth were visible, which were then scraped and transferred into liquid dishes. Culture dishes were kept in absolute sterile conditions at the constant temperature of 21  ºC. Cells needed for experiments were transferred into shaking cultures (120 rpm/min) or washed off every 2 days. In order to make shaking cultures, cells were washed off the plate, transferred to a G0 media (Ax medium containing 100 µ/ml Penicillin and 100 µg/ml Streptomicin), and kept in the shaking incubator at 21  ºC and counted and or diluted every day. Cells were utilised for experiments after 2-3 days of shaking and flasks were kept for one week before replacing them with fresh cultures. The liquid content in flasks was 1/5 of the total flask volume, in order to maintain ideal growth conditions (oxygen and surface area) , and they were be kept between 2 and 5 x 106. Development assay Dictyostelium development assays were performed in triplicate experiments. Cells were plated onto membranes at the concentration of 1 x 107 per membrane (in KK2), then the membranes were transferred onto millipore filters embedded with the selected drug. Cells were placed in small petri dishes (6 cm diameter) and kept at 22  ºC for 24 hours in humid environmental conditions. Development images were taken after 24 hours at different magnification resolutions (x2, x3.2, and x4 side at 45-degree angle). D. discoideum Permanent stock At least 1 x 107 cells were collected from fresh culture plate, and resuspendend in 200ÃŽ ¼l D. discodeum freezing medium (7% DMSO, Horse serum), and frozen to -80 ºC using isopropanol freezing containers for two hours, then stored at -80  ºC in liquid nitrogen. Live cell microscopy To prepare D. discodeum cells (Ax2) for behaviour analysis experiments, cells were grown in shaking suspension in Axenic medium (Formedium Co. Ltd, Norfolk, UK) for at least 48hrs. Cells were washed and resuspended in phosphate buffer at 1.7 x 106 cells/ml. Cells were then pulsed for 5 hours with 30 nM cAMP at 6 min intervals whilst shaking at 120 rpm. Cells were then washed in phosphate buffer, resuspended at 1.7105 cells/ml, and 250  µL aliquots of cells were added to into a Lab-Tek 8-well chambered coverglass wells (Thermo Fisher, Leicestershire, UK), and allowed to adhere for 10-15 min, and for each experiment double concentrated drugs (250  µl) were administrated at the 15th frame by using a P1000. Cells movement was investigated using an Olympus IX71 microscope at 40X magnification, and images were recorded with a QImaging RetigaExi Fast1394 digital camera. Images were acquired every 15 seconds over a 15 min period for each compound, and at each concentration, with a minimu m of three independent experiments for each drug/concentration and an average cell number of 10 cells quantified per experiment. Solvent only controls were carried out for all experiments to ensure readouts were based upon compounds listed, with for example, no effect of DMSO shown at 1% – the highest concentration used in the experiments described here. References Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419. Bachmanov AA, Beauchamp GK (2007). Taste Receptor Genes. Annual Review of Nutrition 27: 389–414. Choi, D.H. et al., 2013. Evaluation of taste-masking effects of pharmaceutical sweeteners with an electronic tongue system. Drug development and industrial pharmacy, 9045, pp.1–10. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23786206 [Accessed October 10, 2013]. Finger, T.E. Kinnamon, S.C., 2011. Taste isn’t just for taste buds anymore. F1000 biology reports, 3(September), p.20. Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3169900tool=pmcentrezrendertype=abstract [Accessed December 9, 2013]. Finger, T.E. Kinnamon, S.C., 2011. Taste isn’t just for taste buds anymore. F1000 biology reports, 3(September), p.20. Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3169900tool=pmcentrezrendertype=abstract [Accessed December 9, 2013]. Gulbransen, B. D., Clapp, T. R., Kinnamon, S. C., Finger, T. E. (2009). NIH Public Access, 99(6), 2929–2937. doi:10.1152/jn.00066.2008.Nasal Holmes, a M., Rudd, J. a, Tattersall, F. D., Aziz, Q., Andrews, P. L. R. (2009). Opportunities for the replacement of animals in the study of nausea and vomiting. British Journal of Pharmacology, 157(6), 865–80. doi:10.1111/j.1476-5381.2009.00176.x Margolskee, R.F., 2002. Molecular mechanisms of bitter and sweet taste transduction. The Journal of biological chemistry, 277(1), pp.1–4. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11696554 [Accessed December 4, 2013]. Meyerhof, W. et al., 2010. The molecular receptive ranges of human TAS2R bitter taste receptors. Chemical senses, 35(2), pp.157–70. Available at: http://www.ncbi.nlm.nih.gov/pubmed/20022913 [Accessed October 17, 2013]. Pulkkinen, V. et al., 2012. The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. American journal of physiology. Lung cellular and molecular physiology, 303(11), pp.L956–66. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22962016 [Accessed September 19, 2013]. Pulkkinen, V. et al., 2012. The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. American journal of physiology. Lung cellular and molecular physiology, 303(11), pp.L956–66. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22962016 [Accessed September 19, 2013]. Robery, S. et al., 2011. Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PloS one, 6(9), p.e24439. Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3169598tool=pmcentrezrendertype=abstract [Accessed October 10, 2013]. Rudnitskaya, A. et al., 2013. Assessment of bitter taste of pharmaceuticals with multisensor system employing 3 way PLS regression. Analytica chimica acta, 770, pp.45–52. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23498685 [Accessed October 10, 2013]. Ueda, T. et al., 2003. Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells. The Journal of neuroscienceà ¢Ã¢â€š ¬Ã‚ ¯: the official journal of the Society for Neuroscience, 23(19), pp.7376–80. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12917372. Wiener, A. et al., 2012. BitterDB: a database of bitter compounds. Nucleic acids research, 40(Database issue), pp.D413–9. Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3245057tool=pmcentrezrendertype=abstract [Accessed October 17, 2013]. Williams, P.B., Crandall, E. Sheppard, J.D., 2010. Azelastine hydrochloride, a dual-acting anti-inflammatory ophthalmic solution, for treatment of allergic conjunctivitis. Clinical Ophthalmology, p.993. Available at: http://www.dovepress.com/azelastine-hydrochloride-a-dual-acting-anti-inflammatory-ophthalmic-so-peer-reviewed-article-OPTH [Accessed February 3, 2014]. Zhang, C.-H., Lifshitz, L. M., Uy, K. F., Ikebe, M., Fogarty, K. E., ZhuGe, R. (2013). The cellular and molecular basis of bitter tastant-induced bronchodilation. PLoS Biology, 11(3), e1001501. doi:10.1371/journal.pbio.1001501 Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3589262tool=pmcentrezrendertype=abstract [Accessed October 15, 2013]. Trufello, a M. et al., 2014. Subclinical concentrations of chlorhexidine inhibit gelatinase activity of carious dentine in vitro. Australian dental journal, pp.1–6. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24494744 [Accessed February 10, 2014].

A Character Analysis of Macbeth in Shakespeares Macbeth :: Free Macbeth Essays

A Character Analysis of Macbeth in Shakespeare's Macbeth By the end of Act V scene v it is clear that Macbeth is not going to rule his kingdom much longer. He is to be killed by a "man none of woman born" (IV,i,80) who we find out latter in the play is Macduff. Before Macbeth is to be killed we find out that he is a great warrior, a sane man, and a superstitious man. In Act I scene ii we find out that Macbeth is a great warrior. We start the scene off from a sergeants account of the fighting against the enemy's of the king and Macbeth. For brave Macbeth-well he deserves that name,-disdaining fortune, with his brandish'd steel, which smok'd with bloody execution. (I,ii,16-18) From this we can tell that Macbeth fought bravely and through unbeatable odds against Macdonwald's army. It also tells us that Macbeth can handle a sword like it was an extension of his own body. The sergeant also tells us: As cannons overcharg'd with double cracks; So they doubly redoubled strokes upon the foe: (I,ii,37-39) From this we can tell that he was a relentless and courageous fighter and would not stop until he had won. He is such a fearless fighter that the day would be remembered for centuries to come the sergeant says: "Or memorize another Golgotha," this tells us that Macbeth would have gone down in the books as Scotland's heroic warrior. Macbeth had two glorious battles both of which he had won. from these battles and the sergeants words we can truly say that Macbeth was a great warrior. Macbeth is also to be portrayed as an insane man, but I think that this is not to be true. An insane man is supposed to be delirious, make no sense what-so-ever, and to enjoy the killing and deaths of others. On the contrary Macbeth is none of these, he in my opinion is a very sane man. Macbeth says to lady Macbeth that "we will proceed no further in this business" (I,vii,31) in this scene Macbeth is showing hesitation in killing Ducan, which tells us that Macbeth like any other normal man does not like killing. In Act II scene I Macbeth has his first major Soliloquy where he seems to be delirious by seeing a dagger floating around him "A dagger of the mind, a false creation" (II,i,38). I think that this in fact is just his imagination telling him that it is a mistake to kill Ducan. Macbeth has a very stressful decision on his mind whether to compel to the

Where Women Lead The Show †Renoir’s Acrobats At The Cirque Fernando, 1879

Pierre-Auguste Renoir’s Acrobats At The Cirque Fernando, 1879 shows two young girls, most probably between twelve and fifteen years of age, taking turns to perform their act at the circus. One of the young girls is carrying balls around her chest while the other is communicating with the audience as part of her act. The girl who is communicating with the audience has a questioning, innocent expression on her face. The one who is carrying balls is possibly waiting for her turn to perform. She, too, is innocent and fresh in appearance as the other. However, she seems to be dwelling on her new experiences of semi-adulthood. Perhaps she is musing on the boys in her life – the young men who admire her very much. The audience depicted in the painting, behind the bodies of the two young girls, appears to consist of men alone after all. The men appear like judges, in their black coats, giving them the semblance of uniformed officers. Only one of the men has his face visible through the painting, and the face is hard enough for the girls to display their innocence in all its glory with the assumption that the counterpart of a harsh and doubtful attitude must be softness. Although the girl carrying the balls has her back turned toward the hard faced man, she knows that she too would have to perform. The expressions of the male and the females in Renoir’s Acrobats At The Cirque Fernando, 1879 are rather similar to the expressions of the two sexes depicted in many of the artist’s works of the time. The woman is seen as the adored and innocent object that performs, even though the man is hard faced, perhaps weary of the work that he performs to fend for his family day after day. The woman is the amuser, the muse, and the object of entertainment to fend for. After all, she is beautiful. The only beautiful facet of the man is that he is strong – in Renoir’s paintings, at least. What is more, the man is always staring at the woman in Renoir’s works. He fondles her whenever he has the chance. The woman remains faithful to him – this is depicted through the innocence on her face. If she becomes unfaithful she knows that the hard faced man would discontinue supporting her. The French word for ‘thank you’ is merci, which, if used in English, perfectly describes the attitude of the woman in late nineteenth century Paris. Although Paris was one of the first places in the west where women were generally believed to have been liberated, Renoir’s painting reveals that the women were definitely not liberated through promiscuity or debauchery. Rather, the urban Parisian women in the late nineteenth century seem to have been given permission by their men to be out and about, entertaining them, while remaining faithful to their innocence as well as their marital vows. As the facial expression of the young girl carrying the balls in Renoir’s Acrobats At The Cirque Fernando, 1879 reveals – women understood their position in Parisian society even as they were aware that men and women are equally dependent on each other. Perhaps they also knew that men could turn violent against the woman – the epitome of mercy – and that their partners may very well become harsh and cruel if they were not obeyed according to divine laws that are believed to demand that they become subservient unto men. Although these beliefs continue to be nurtured in many parts of the world, Renoir’s Acrobats At The Cirque Fernando, 1879 is a reminder that divine laws may have been misconstrued as well!

Weapons of Mass Destruction

The term Weapons of Mass Destruction has two indications. In its broader, literal sense, it is used to refer to weapons whose destructive power far surpasses that of guns or conventional explosives. However, the term is more often used in a narrower sense, to refer specifically to nuclear, biological, and chemical weapons. Since the September 11, 2001, terrorist attacks, which raised awareness of America’s vulnerability, the United States has greatly intensified its efforts to stop the spread of nuclear, biological, and chemical weapons.When the president and other officials refer to â€Å"weapons of mass destruction,† they usually mean NBC weaponry. An organism or toxin found in nature is used in them that is meant to kill or incapacitate an enemy. Though there are different types and they are made up of different ingredients, they are all meant to kill and do significant destruction. The United States Military refers to them as â€Å"weapons that are capable of high order destruction and being used to destroy large numbers of people. † Many countries posses weapons of mass destruction for one main cause.Because they â€Å"generate a culture of fear†, they are held in reserve by countries as a scare tactic. They are set aside to be used as a threat, if another country were to use them, they would in turn be bombed with weapons of mass destruction. During the Cold War, the term â€Å"weapons of mass destruction† was primarily a reference to nuclear weapons. At the time, in the West the euphemism â€Å"strategic weapons† was used to refer to the American nuclear arsenal, which was presented as a necessary deterrent against nuclear or conventional attack from the Soviet Union.The term â€Å"weapons of mass destruction† continued to see periodic use throughout this time, usually in the context of nuclear arms control; Ronald Reagan used it during the 1986 Reykjavik Summit, when referring to the 1967 Outer Space Trea ty. Reagan's successor, George H. W. Bush, used the term in an 1989 speech to the United Nations, using it primarily in reference to chemical arms. The end of the Cold War reduced U. S. reliance on nuclear weapons as a deterrent, causing it to shift its focus to disarmament. This period coincided with an increasing threat to U. S. nterests from Islamic nations and independent Islamic groups. With the 1990 invasion of Kuwait and 1991 Gulf War, Iraq's nuclear, biological, and chemical weapons programs became a particular concern of the first Bush Administration. Following the war, Bill Clinton and other western politicians and media continued to use the term, usually in reference to ongoing attempts to dismantle Iraq's weapons programs. After the September 11, 2001 attacks and the 2001 anthrax attacks, an increased fear of non-conventional weapons and asymmetrical warfare took hold of the United States and other Western powers.This fear reached a crescendo with the 2002 Iraq disarmame nt crisis and the alleged existence of weapons of mass destruction in Iraq that became the primary justification for the 2003 invasion of Iraq. However, no WMD were found in Iraq. Due to the indiscriminate impact of WMDs, the fear of a WMD attack has shaped political policies and campaigns, fostered social movements, and has been the central theme of many films. Support for different levels of WMD development and control varies nationally and internationally.Yet understanding of the nature of the threats is not high, in part because of imprecise usage of the term by politicians and the media. Fear of WMD, or of threats diminished by the possession of WMD, has long been used to catalyze public support for various WMD policies. They include mobilization of pro- and anti-WMD campaigners alike, and generation of popular political support. The term WMD may be used as a powerful buzzword, or to generate a culture of fear. It is also used ambiguously, particularly by not distinguishing amo ng the different types of WMD.A television commercial called Daisy, promoting Democrat Lyndon Johnson's 1964 presidential candidacy, invoked the fear of a nuclear war and was an element in Johnson's subsequent election. More recently, the threat of potential WMD in Iraq was used by President George W. Bush to generate public support for the 2003 invasion of Iraq. Broad reference to Iraqi WMD in general was seen as an element of President Bush's arguments. As Paul Wolfowitz explained: â€Å"For bureaucratic reasons, we settled on one issue, weapons of mass destruction, because it was the one reason everyone could agree on. To date, however, Coalition forces have found mainly degraded artillery shells.There was almost no dissent on the issue. Molly Ivins wrote : â€Å"the ONLY source to report skeptically on the administration's claims about Iraq's weapons of mass destruction before the war? Knight-Ridder and its terrific reporters Warren Strobel and Jonathan Landay. â€Å". On Jun e 21, 2006, United States Senator Rick Santorum claimed that â€Å"We have found weapons of mass destruction in Iraq, chemical weapons. According to the Washington Post, he was referring to 500 such shells â€Å"that had been buried near the Iranian border, and then long forgotten, by Iraqi troops during their eight-year war with Iran, which ended in 1988. † That night, â€Å"intelligence officials reaffirmed that the shells were old and were not the suspected weapons of mass destruction sought in Iraq after the 2003 invasion of Iraq. † The shells had been uncovered and reported on in 2004. In 2004 Polish troops found nineteen 1980s-era rocket warheads, thwarting an attempt by militants to buy them at $5000 each.Some of the rockets contained extremely deteriorated nerve agent. Limits on WMD by the US scare allied countries. The US nuclear umbrella is the primary contributor to the security of Europe and for Asia. Lack of confidence in the US umbrella causes European n ations to either build up their current arsenals, or embark on entirely new nuclear weapons programs. Nuclear proliferation in Europe causes massive instability there because of the threat it poses to Russia. Asian proliferation threatens conflicts with China.The odds that an asteroid that could potentially wipe out all life on earth are high. A massive asteroid may have been responsible for the extinction of the dinosaurs. The only defense earth has against these asteroids is nuclear weapons. Were we to disarm completely, we would be unable to shoot down an incoming asteroid, condemning all life to extinction. The military-industrial complex is a powerful constituency in the US. Limits on one type of WMD scare the military-industrial complex. They will feel frightened that the US will be unable to defend itself without its current array of weaponry.To compensate, they will develop new forms of WMDs that are even more destructive, like nanotechnology. Any arms control initiative req uires a substantial outlay of money to implement. Decommissioning weapons systems takes funds. Verifiable agreements demand substantial investment in inspections and monitoring. The US cannot afford to spend more money, given the precarious situation its budget is in. Busting the budget could have a terrible effect on the economy, perhaps triggering an economic collapse